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League: NFLSport: FootballCountry: United StatesCategory: Scores & Results

49ers, Eagles top Week 2 fantasy defense picks for NFL showdown

Yahoo Sports • 1 min read • Latest: Sep 15, 2026, 2:43 PM

Last updated Sep 15, 2026

49ers, Eagles top Week 2 fantasy defense picks for NFL showdown
Summary

In preparation for Week 2 of the 2026 NFL season, teams such as the San Francisco 49ers and Philadelphia Eagles are highlighted as key fantasy football defenses. The 49ers performed strongly against the Los Angeles Rams in Australia, while the Eagles look to rebound after a shaky performance against the Commanders. Other recommended defenses include the Seattle Seahawks, Houston Texans, and Kansas City Chiefs, each expected to face favorable matchups. The chaotic early season is noted for its unpredictability among defenses, with many managers opting for streaming players rather than relying on drafted high-end units. Teams are urged to avoid panic after disappointing Week 1 performances.

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By the Numbers
  • •San Francisco 49ers excelled in Week 1 against the Rams.
  • •Philadelphia Eagles seek improvement against the Titans.
  • •Seattle Seahawks face Arizona Cardinals, strong potential for a bounce-back.
  • •Houston Texans expected to perform well against Cincinnati Bengals.
  • •Kansas City Chiefs show defensive strength ahead of Colts matchup.
Latest Updates
  • 2:43 PMYahoo Sports — Getting Defensive: Week 2 fantasy plays led by 49ers, Eagles; top streaming defenses
What they're saying
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Gary Davenport breaks down the fantasy football defense landscape headed into Week 2 of the 2026 NFL season.

Related Teams & Leagues
Arizona CardinalsCincinnati BengalsHouston TexansJacksonville JaguarsLas Vegas RaidersLos Angeles RamsNFLFootball

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