49ers edge Cardinals 36-30 in tight contest, but injuries mount

Yahoo Sports • 1 min read • Latest: Sep 28, 2026, 12:38 AM

Last updated Sep 28, 2026

49ers edge Cardinals 36-30 in tight contest, but injuries mount
Summary

The San Francisco 49ers secured a 36-30 victory over the Arizona Cardinals on September 27 in Santa Clara. Deebo Samuel highlighted the win with an 80-yard touchdown run, while Brock Purdy had his toughest game with only 14 completions on 26 attempts for 215 yards. The 49ers, now 3-0, are grappling with significant injuries, losing wide receiver Mike Evans and 12-time Pro Bowl left tackle Trent Williams during the game. The defense, missing key players including Nick Bosa, allowed the Cardinals to challenge them after halftime. Following this win, the 49ers will look to maintain their unbeaten start amid evolving injury concerns.

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By the Numbers
  • •49ers improve to 3-0 for the season.
  • •Deebo Samuel scores an 80-yard touchdown.
  • •Brock Purdy completed 14 of 26 passes.
  • •Injuries included Mike Evans and Trent Williams.
  • •Cardinals made a strong push in the second half.
Latest Updates
  • 12:38 AMYahoo Sports — 49ers hang on to beat Cardinals, but win may prove to be too costly
What they're saying
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SANTA CLARA — Deebo Samuel caught the pitch from Mike Evans and was off to the races. Right behind him were the rest of the San Francisco 49ers, who were...

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