49ers face Cardinals amid significant injuries in Santa Clara
Yahoo Sports • 1 min read • Latest: Sep 27, 2026, 8:12 PM
Last updated Sep 27, 2026
The San Francisco 49ers are set to play against the Arizona Cardinals on September 27, 2026. The 49ers have been challenged by injuries, especially to key defensive players including Nick Bosa. Despite these challenges, the 49ers' offense, led by quarterback Brock Purdy, aims to maintain momentum. The game takes place at Levi's Stadium in Santa Clara, California, and highlights the team's depth issues on defense as they look for ways to counter the Cardinals.
- •Game held at Levi's Stadium, Santa Clara, California.
- •49ers are missing several key defensive players, including Nick Bosa.
- •Brock Purdy has started the season strong for the 49ers.
- •The game is crucial for both teams as they seek a winning record.
- •Injuries have forced the 49ers to rely on depth players.
- 8:12 PMYahoo Sports — 49ers-Cardinals game thread: Can the Niners overcome all the injuries?
"The 49ers take on the Cardinals. This is our game thread.
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