49ers face Cardinals as injury concerns mount before Week 3 matchup
Yahoo Sports • 1 min read • Latest: Sep 27, 2026, 2:55 PM
Last updated Sep 27, 2026

The San Francisco 49ers will host the Arizona Cardinals in an NFC West matchup on Sunday. San Francisco enters the game after a decisive victory over Miami, but will be without star pass rusher Nick Bosa due to a calf injury. Arizona is struggling after a loss to Seattle, having dropped seven straight NFC West games dating back to last season. Quarterback Jacoby Brissett has shown improvement in his scoring ability, but Arizona has struggled overall as they visit a formidable 49ers team.
- •49ers coming off a significant victory over the Dolphins
- •Bosa will miss time with a calf injury
- •Cardinals lost to the Seahawks in Week 2
- •Arizona has lost seven straight NFC West games
- •Brissett has a 25/9 TD/INT ratio this season
- 2:55 PMYahoo Sports — 49ers numbers to know: The Cardinals have a long NFC West streak on the line
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