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49ers face defensive challenges ahead of game against Cardinals

Yahoo Sports • 1 min read • Latest: Sep 26, 2026, 12:00 PM

Last updated Sep 26, 2026

49ers face defensive challenges ahead of game against Cardinals

Summary

The San Francisco 49ers prepare to host the Arizona Cardinals on Sunday amid significant injuries on their defensive line. Osa Odighizuwa is one of only three defensive linemen from the initial 53-man roster still available, following a series of injuries, including a severe calf issue for All-Pro Nick Bosa. As the 49ers adjust their lineup, they face the task of containing the Cardinals' running attack, led by Tyler Allgeier and rookie Jeremiyah Love. The 49ers are expected to use recently signed players to strengthen their defensive presence against Arizona.

Source Links

Yahoo Sports

Status Watch

•Nick Bosa suffers a calf injury during warm-ups.
•Osa Odighizuwa highlights team's defensive challenges this season.
•49ers to field a patchwork defensive line against Cardinals' rushing attack.
•Brock Purdy has historically performed well against Arizona defenses.

Latest Updates

12:00 PMYahoo Sports — Can 49ers stop Cardinals' ground game amid defensive-line crisis? ‘It's definitely crazy'

What they're saying

"
Osa Odighizuwa has played in 73 straight games. He doesn't know who'll be next to him on the 49ers' patchwork defensive line against the Cardinals. "I have never seen anything like this."
— Yahoo Sports

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