49ers face roster shortages for Week 1 game against the Rams

The San Francisco 49ers enter their Week 1 NFL matchup against the Los Angeles Rams with significant roster limitations due to injuries and personnel turnover. Josh Dubow of The Associated Press reports that Renardo Green is the team's only player drafted in the first or second round from 2020 through 2025 who will be active for the season opener. Multiple recent high-round draft picks are unavailable, including 2025 first-rounder Mykel Williams, who will miss at least four games, and 2026 second-rounder Alfred Collins, who is sidelined for the season. First-round pick Ricky Pearsall is also out for the 2026 season due to injury. Brandon Aiyuk remains with the organization but is currently away from the team, while other former high-round selections have either departed or are no longer on the roster. The team continues to navigate these availability issues as they prepare for the game overseas.

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