49ers look to exploit Cardinals' defensive miscommunications this week

The San Francisco 49ers are preparing to face the Arizona Cardinals on Sunday, September 27, 2026. In a recent press conference, 49ers players noted the challenges presented by the Cardinals' shifting defensive looks, particularly their use of Cover 6. Arizona’s defensive coordinator Nick Rallis has been under scrutiny for missed assignments and defensive complexities. The 49ers hope to capitalize on these weaknesses, especially given the injury struggles within Arizona's secondary. Ongoing discussions around the 49ers' performance in the trenches and updates on player Gracen Halton reflect their diligence ahead of the matchup.

• 9:04 AMYahoo Sports — Golden Nuggets: Kyle’s scheme will hopefully be Raising Arizona’s miscommunications on defense