49ers offense faces tough test against Seahawks defense in Week 5

The San Francisco 49ers (4-0) will meet the Seattle Seahawks (3-1) on Sunday in Seattle, marking a significant early-season NFC West matchup. Analysts highlight the formidable challenge the 49ers' offense faces against a strong Seahawks defense, particularly as both teams contend for playoff positioning. Quarterback Brock Purdy leads a 49ers offense that has not allowed a sack this season, while the Seahawks, known for their stout defensive front, aim to disrupt this streak. Key injuries may impact both teams' run games, with Kyle Juszczyk likely sidelined for San Francisco, raising questions about their running efficiency against a disciplined Seattle defense. The clash is expected to demand strategic adjustments from both head coaches, Kyle Shanahan and Mike Macdonald.

• 1:24 AMYahoo Sports — 'Football 301' on 49ers vs. Seahawks: Brock Purdy and his offensive machine face their biggest test