49ers, Seahawks clash in key NFC West matchup Sunday
Yahoo Sports • 1 min read • Latest: Oct 8, 2026, 7:15 PM
Last updated Oct 8, 2026

The San Francisco 49ers face off against the Seattle Seahawks this Sunday in a critical NFC West matchup, with both teams looking to establish momentum early in the season. The 49ers are boasting a strong offensive performance, while the Seahawks will aim to leverage their defensive strategies. In addition to this game, the Las Vegas Raiders visit the New England Patriots and the Buffalo Bills travel to the Los Angeles Rams, where Matthew Stafford will seek to improve after mixed results this season. Experts are highlighting key matchups, including the Minnesota Vikings at New Orleans Saints and the Baltimore Ravens without Lamar Jackson against the Atlanta Falcons.
- •49ers and Seahawks meet in an NFC West showdown on Sunday
- •Matthew Stafford seeks better performance against the Bills
- •Raiders will take on the Patriots this Sunday
- •Key matchups include Vikings at Saints and Ravens at Falcons
- •Bold predictions suggest breakout performances for various players
- 7:15 PMYahoo Sports — NFL Week 5 preview & bold predictions: Can Stafford get right vs. Bills? 49ers-Seahawks hoss fight
"Nate Tice & Matt Harmon preview the biggest games of Week 5 of the NFL season.
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