49ers seek replacement for Alfred Collins after season-ending knee injury
USA Today • 1 min read • Latest: Sep 9, 2026, 3:20 AM
Last updated Sep 9, 2026

The San Francisco 49ers are adjusting their defensive roster ahead of the team's regular season opener against the Los Angeles Rams. The team lost defensive tackle Alfred Collins to a season-ending knee injury during preparations for the game. Coaches are currently evaluating three potential options to fill the void on the defensive line. One candidate has emerged as the primary choice to step into the role immediately. The organization is working through these roster changes in the hours leading up to the season debut. No formal announcement regarding the final replacement has been made as the team scrambles to address the vacancy.
- •Alfred Collins sustained a season-ending knee injury.
- •The 49ers are evaluating three players as potential replacements.
- •San Francisco plays the Los Angeles Rams in the season opener.
- •One player is considered the primary option to start at defensive tackle.
- 3:20 AMUSA Today — 49ers have 3 options to replace Alfred Collins after brutal injury - Niners Wire
"The San Francisco 49ers have three names, but one real option to immediately replace Alfred Collins following his knee injury.
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