Buffalo Bills score 41-31 victory over Detroit Lions in season opener

The Buffalo Bills opened Highmark Stadium with a decisive 41-31 victory against the Detroit Lions in their Week 2 matchup on September 18, 2026. Josh Allen led the Bills to their second win of the season with five total touchdowns, generating strong national speculation about the Bills as potential Super Bowl contenders. Analysts praised the offensive and defensive performances, noting standout plays from players like Deone Walker and Dalton Kincaid. Following the game, media reactions highlighted the Bills' offensive prowess and the effectiveness of their game plan, as they look to maintain momentum moving forward in the season.

• 11:45 AMYahoo Sports — National reactions: Many Bills Super Bowl predictions made after Lions win