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Cardinals face 49ers amid struggles in recent meetings

Yahoo Sports • 1 min read • Latest: Sep 25, 2026, 7:17 PM

Last updated Sep 25, 2026

Cardinals face 49ers amid struggles in recent meetings

Summary

The Arizona Cardinals are set to play the San Francisco 49ers on Sunday. They have struggled against the 49ers recently, losing six of the last eight matchups, including both games last season. The Cardinals' overall record against the 49ers is 31-38, with their last significant success from 2015 to 2018, when they won eight consecutive games. Quarterback Brock Purdy has had success against the Cardinals, winning five of six starts. This matchup features first-year head coach Mike LaFleur, who previously worked with 49ers head coach Kyle Shanahan.

Source Links

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By the Numbers

•Cardinals lost six of their last eight games against the 49ers.
•Purdy is 5-1 in his career starts against the Cardinals.
•Arizona has an 8-0 run against San Francisco from 2015-2018.
•Mike LaFleur faces his former mentor, Kyle Shanahan, in this matchup.

Latest Updates

4:57 AMYahoo Sports — Cardinals’ 49ers Loss Extends Alarming NFC West Streak
7:17 PMYahoo Sports — Cardinals vs. 49ers history: Arizona struggling in recent meetings

What they're saying

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The Arizona Cardinals‘ performance against the NFC West has gotten historically bad following their most recent loss.Sunday’s loss to the San Francisco 49ers gives the Cardinals eight straight losses against their NFC West rivals going back to the beginning of the 2025 season. Their record against the NFC West since the start of the 2022 […] The post Cardinals’ 49ers Loss Extends Alarming NFC West Streak appeared first on HEAVY.
— Yahoo Sports