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Cardinals face 49ers in pivotal Week 3 matchup in Santa Clara

Yahoo Sports • 1 min read • Latest: Sep 26, 2026, 6:21 PM

Last updated Sep 26, 2026

Cardinals face 49ers in pivotal Week 3 matchup in Santa Clara
Summary

The Arizona Cardinals are set to play the San Francisco 49ers on Sunday in Santa Clara. Both teams enter the matchup with differing narratives; the 49ers are enjoying a 2-0 start, bolstered by quarterback Brock Purdy's performance and an effective offensive scheme. The team is also dealing with injuries on the defensive line, impacting their strategy. As for the Cardinals, they hope for a stronger offensive showing compared to last week, with key players needing to step up against a formidable opponent. The game promises to be crucial for both sides' early season trajectories.

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Yahoo Sports
Status Watch
  • •Cardinals and 49ers meet for Week 3 on September 29.
  • •49ers hold a strong start with a 2-0 record this season.
  • •Brock Purdy leads an efficient 49ers offense amidst defensive injuries.
  • •Key matchups expected between Cardinals' pass-catchers and 49ers' defense.
  • •Injuries could significantly impact both teams' strategies.
Latest Updates
  • 6:21 PMYahoo Sports — Cardinals vs. 49ers opponent preview: Keys, matchups, predictions
What they're saying
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Niners Wire lead writer Kyle Madson answers questions and makes predictions about the Week 3 Cardinals-49ers game.

Related Teams & Leagues
Arizona CardinalsSan Francisco 49ersNFLFootball

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