Christian McCaffrey faces injury uncertainty before 49ers opener against Rams

The San Francisco 49ers enter their Thursday night season opener against the Los Angeles Rams in Australia while managing an injury to running back Christian McCaffrey. The veteran, entering his age-30 season, is listed on the injury report alongside teammates George Kittle and Mike Evans. McCaffrey experienced recurring calf and Achilles injuries during the 2024 season, which limited his participation to four games. Team officials have provided limited information regarding his status for the upcoming game. San Francisco rostered Kaelon Black and Jordan James as depth options at the running back position should McCaffrey be unavailable. The team's late-game schedule in the Pacific Time Zone complicates roster decisions for managers awaiting final confirmation of lineup availability.

• 6:01 PMYahoo Sports — Christian McCaffrey injury: Status of 49ers RB for Thursday's opener and what it could mean for fantasy football