Deebo Samuel Sr. faces challenging fantasy start against Rams in Week 1

Fantasy managers are advised to exercise caution with Deebo Samuel Sr. as the NFL season opens this week. Pro Football Network analysts currently rank the wide receiver outside the top 50 at his position ahead of the matchup against the Rams. The Rams held one of the league's most effective defenses against passes after the catch last year, and expectations for their secondary remain high. While Samuel joined the Niners offense with the intent of securing a role as a primary target earner, his average depth of target has trended downward over the last two seasons. Analysts suggest waiting to see how Samuel fits into the new system before relying on him in starting fantasy lineups. Despite his track record of catching six or more passes in four of five games during the start of the 2025 season, the Week 1 environment appears unfavorable.

• 5:05 PMYahoo Sports — Deebo Samuel Sr. Fantasy Week 1 Start or Sit: Wait Out the Dud