Lions face Bills in Thursday night football matchup at Highmark Stadium
Yahoo Sports • 1 min read • Latest: Sep 17, 2026, 4:01 AM
Last updated Sep 17, 2026
The Detroit Lions are set to play the Buffalo Bills on September 17 at Highmark Stadium in Orchard Park, New York. Both teams are coming off Week 1 performances where the Lions' defense struggled against the Saints, while the Bills scored 36 points against the Texans. Predictions from The Detroit News indicate the Bills' potent offense, led by Josh Allen, could capitalize on Detroit's defensive weaknesses. Analysts expect a competitive game with the Bills favored to win. The game will air at 8:15 p.m. on Amazon Prime Video.
- •Lions play Bills on September 17 at Highmark Stadium.
- •Lions' defense allowed eight explosive plays against the Saints.
- •Bills scored 36 points against the Texans in their opener.
- •Predictions favor the Bills, with a potential close score.
- •Josh Allen has been effective against the Lions in past matchups.
- 4:01 AMYahoo Sports — Predictions: Lions at Buffalo Bills
"Nolan Bianchi, Richard Silva, John Niyo and Bob Wojnowski of The Detroit News offer predictions for Thursday's game between the Lions and Bills.
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