Lions prepare to face Cardinals in key Week 5 matchup
Yahoo Sports • 1 min read • Latest: Oct 10, 2026, 4:01 AM
Last updated Oct 10, 2026

The Detroit Lions are set to face the Arizona Cardinals on Sunday at State Farm Stadium in Glendale, Arizona. Both teams have been inconsistent this season, with the Lions holding a 2-2 record and the Cardinals at 1-3. The Lions' defense, ranked last in the league in yards and points allowed, will need to improve against a Cardinals offense led by quarterback Jacoby Brissett. Predictions from analysts suggest a high-scoring affair, with projections favoring the Lions to secure a much-needed win to head into their bye week with a better record.
- •Game scheduled for Sunday, October 10, at 4:25 p.m. ET.
- •Lions enter at 2-2 and Cardinals at 1-3.
- •Lions defense struggling, ranked last in the league.
- •Analysts predict a high-scoring game, with predictions favoring the Lions.
- •A win is crucial for Detroit before their bye week.
- 4:01 AMYahoo Sports — Predictions: Lions at Arizona Cardinals
"Nolan Bianchi, Richard Silva, John Niyo and Bob Wojnowski of The Detroit News offer predictions for Sunday's game between the Lions and Cardinals.
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