Los Angeles Rams and San Francisco 49ers play in Melbourne

The Los Angeles Rams and the San Francisco 49ers open the NFL season on September 10 at the Melbourne Cricket Ground in Australia. Kickoff for this Thursday Night Football matchup is scheduled for 5:35 p.m. PDT. This game marks the first time the league has hosted a regular-season contest in the country. San Francisco holds a 79-72-3 lead in the all-time series against Los Angeles, though the Rams have won four of their last five meetings. Coaches Sean McVay and Kyle Shanahan enter the game with Shanahan holding an 11-8 record in their head-to-head history since 2017. For the Rams, Myles Garrett and Puka Nacua are expected to play after missing portions of training camp, while Aaron Donald will not participate as he continues to ramp up his activity.

• 12:02 PMYahoo Sports — Rams vs 49ers: How to watch on TV, stream or listen on radio