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Louisville faces No. 10 Ole Miss in 2026 season opener in Nashville

Yahoo Sports • 1 min read • Latest: Sep 6, 2026, 10:01 AM

Last updated Sep 6, 2026

Louisville faces No. 10 Ole Miss in 2026 season opener in Nashville

Summary

Louisville opens its 2026 college football season today with a matchup against No. 10 Ole Miss in Nashville. Cardinals head coach Jeff Brohm enters the game with a 5-8 career record against top-10 opponents, including victories over No. 8 Clemson in 2024 and No. 2 Miami in 2025. Brohm has established a reputation for challenging high-ranked programs throughout his 12 seasons as a head coach. His career record against top-10 teams improved to 5-4 starting in 2018. While he has experienced losses to elite competition, his offensive scheme often remains a focal point for opposing defensive units. The matchup serves as a barometer for both programs as they begin their respective campaigns.

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By the Numbers

•Louisville plays No. 10 Ole Miss today in Nashville.
•Jeff Brohm holds a 5-8 career record against top-10 opponents.
•Brohm has secured wins over ranked programs like Miami and Clemson since joining Louisville.
•The Louisville head coach previously earned the nickname Spoilermakers while at Purdue.

Latest Updates

10:01 AMYahoo Sports — Jeff Brohm has a history of top-10 upsets. Should Ole Miss be on alert vs Louisville?

What they're saying

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Louisville's Jeff Brohm has a history of notching top-10 upsets. As his Cardinals prepare to face No. 10 Ole Miss, here's a look at those games
— Yahoo Sports

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