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Louisville football prepares for opening game against Ole Miss in Nashville

Yahoo Sports • 1 min read • Latest: Sep 2, 2026, 9:10 AM

Last updated Sep 2, 2026

Louisville football prepares for opening game against Ole Miss in Nashville

Summary

The Louisville Cardinals open their 2026 season against the Ole Miss Rebels in Nashville. NBC Sports analyst Nicole Auerbach ranked Louisville at No. 16 on her Associated Press Top 25 ballot, citing the roster assembled by coach Jeff Brohm. The team features running back Isaac Brown, who is expected to play a central role in the offense. Brohm enters the season looking to maintain his track record of success in high-profile non-conference games. The program remains a subject of national discussion regarding potential College Football Playoff contention for the 2026 season.

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By the Numbers

•Louisville plays Ole Miss in Nashville to open the 2026 season.
•Nicole Auerbach ranked Louisville No. 16 in the Associated Press Top 25.
•Jeff Brohm returns as head coach for the Louisville football program.
•Running back Isaac Brown is a focal point of the Louisville offense.

Latest Updates

9:10 AMYahoo Sports — Can Louisville football get on Playoff track with win over Ole Miss?

What they're saying

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NBC Sports college insider Nicole Auerbach is high on Jeff Brohm's Louisville Cardinals in 2026. Hear why on this episode of The C.L. Brown Show.
— Yahoo Sports

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