Louisville, Wake Forest prepare for ACC clash in Week 4 matchup
Yahoo Sports • 1 min read • Latest: Sep 21, 2026, 9:11 AM
Last updated Sep 21, 2026

Louisville football faces Wake Forest in an ACC contest on September 21, 2026, with the Cardinals holding a 2-1 record. Louisville aims to build on a recent win over SMU after a season-opening loss to Ole Miss. Wake Forest is coming off a close loss to Miami and looks to improve its performance after a series of penalties affected that game. The matchup will feature key players like Louisville's Kaleb Beasley and Wake Forest's Gio Lopez, each contributing significantly to their teams' overall efforts this season. Both squads will strive for a cleaner game to enhance their chances of victory as they continue in conference play.
- •Louisville enters with a 2-1 record in the ACC.
- •Wake Forest lost a close game against Miami, falling 33-20.
- •Isaac Brown's performance is key for Louisville's run game.
- •Kaleb Beasley excelled with 10 tackles and two interceptions against SMU.
- •Gio Lopez is averaging 296.7 passing yards for Wake Forest.
- 9:11 AMYahoo Sports — Storylines, players to watch in Louisville's ACC game vs Wake Forest
"Louisville football heads into its ACC game against Wake Forest with a 2-1 record. Here are storylines and players to watch in the Week 4 contest.
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