Matthew Stafford sets NFL record for most pick-sixes in loss to Broncos

In a game on September 27, 2026, Matthew Stafford of the Los Angeles Rams threw a critical pick-six to Denver Broncos linebacker Talanoa Hufanga, turning a Rams lead into a deficit late in the fourth quarter. This mistake made Stafford the all-time leader in pick-sixes with 33, surpassing Brett Favre's previous record of 32. The Rams and Broncos showcased strong offensive performances at various points, but the turnover proved decisive. Stafford's misstep ignited the crowd at Empower Field in Denver, shifting momentum and contributing to the game's outcome.

• 3:50 AMYahoo Sports — Matthew Stafford makes wrong kind of NFL history with pick-six vs. Broncos