NFL Week 4 predictions include close matchups for key games

Yahoo Sports • 1 min read • Latest: Sep 28, 2026, 4:00 PM

Last updated Sep 28, 2026

NFL Week 4 predictions include close matchups for key games
Summary

As NFL Week 4 approaches, predictions highlight several crucial matchups on the schedule. The Pittsburgh Steelers are anticipated to face the Cleveland Browns, with concerns over Deshaun Watson's performance against Pittsburgh's pass rush. The Indianapolis Colts are expected to challenge the Washington Commanders, though the outcome could hinge on who starts at quarterback. In another notable game, the Buffalo Bills are favored over the New England Patriots, where turnovers may play a significant role. The Jacksonville Jaguars and Cincinnati Bengals game is anticipated to be closely contested, with defensive performance likely pivotal. Many eyes will also be on the Chicago Bears versus the New York Jets, particularly regarding injuries to key players.

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By the Numbers
  • •Pittsburgh Steelers favored over Cleveland Browns on Thursday night
  • •Indianapolis Colts face Washington Commanders in NFL London Game
  • •Buffalo Bills expected to top New England Patriots
  • •Jacksonville Jaguars take on Cincinnati Bengals in a key clash
  • •Chicago Bears match up against New York Jets amid injuries
Latest Updates
  • 4:00 PMYahoo Sports — NFL Week 4 Predictions: Picks for Every Game on NFL Schedule This Week
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Week 3 of the 2026 NFL season delivered ample chaos, with multiple 2-0 teams going down in surprising upsets and […]

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