Nick Bosa joins lengthy injury list for 49ers, sidelined weeks

Yahoo Sports • 1 min read • Latest: Sep 25, 2026, 6:12 PM

Last updated Sep 25, 2026

Nick Bosa joins lengthy injury list for 49ers, sidelined weeks
Summary

San Francisco 49ers star pass rusher Nick Bosa is expected to miss multiple weeks due to a calf injury. This development comes as the 49ers are already dealing with injuries to several key players, including Alfred Collins, Mykell Williams, and multiple wide receivers on injured reserve. Despite a strong start to the season at 2-0, the team is grappling with a growing injury crisis that has historically affected their performance. As they approach a demanding schedule with three home games in their next four contests, the 49ers face the challenge of maintaining momentum while managing their depleted roster.

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Status Watch
  • •Bosa injured his calf and will be out for multiple weeks.
  • •The 49ers' defensive line is significantly impacted with multiple injuries.
  • •San Francisco holds a 2-0 record but has serious injury concerns.
  • •Older roster may be contributing to the injury frequency.
Latest Updates
  • 6:12 PMYahoo Sports — Making sense of yet another 49ers rash of injuries, with Nick Bosa the latest victim
What they're saying
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The 49ers' bad injury luck has been going on for most of Kyle Shanahan's time in San Fran, but also before that.

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