Ole Miss football prepares to face Louisville running back Isaac Brown

Ole Miss football travels to Nashville to face Louisville at Nissan Stadium on September 6. Defensive coordinator Pete Golding characterized the challenge as difficult, noting that the Rebels must contain Isaac Brown, a junior running back he identified as one of the most explosive players on the schedule. To prepare for the matchup, the Ole Miss defense has relied on intense 11-on-11 practice sessions against running back Kewan Lacy. Golding emphasized that these reps are vital for building game-speed conditioning and tackling fundamentals. The Rebels struggled against the run during the 2025 season, finishing 12th in the SEC in rushing defense. With quarterback Trinidad Chambliss and Lacy leading the offense, the team aims to improve its defensive efficiency against Louisville’s run-heavy scheme under coach Jeff Brohm.

• 8:27 PMYahoo Sports — How Kewan Lacy helped Ole Miss football prepare for Louisville star RB Isaac Brown