Philadelphia Eagles rank first in Fantasy Football Defense Week 2
Yahoo Sports • 1 min read • Latest: Sep 20, 2026, 12:05 PM
Last updated Sep 20, 2026

The Philadelphia Eagles lead the Week 2 fantasy football defense rankings ahead of their road game against Tennessee. They are followed by the Seattle Seahawks, Los Angeles Chargers, Los Angeles Rams, and Tampa Bay Buccaneers in the top five. The San Francisco 49ers secure the sixth spot against a depleted Miami team. The Seahawks are expected to perform well against Arizona, leveraging a possible high-volume passing game. Meanwhile, the 49ers' improved pressure from their Week 1 performance could also create opportunities for fantasy points this week as they face Miami at home.
- •Eagles play Tennessee, ranked No. 1 in defenses.
- •Seahawks could benefit from Arizona's pass-heavy game script.
- •49ers generated high pressure rates in Week 1 against Miami.
- •Chargers and Rams round out top five defenses for Week 2.
- 12:05 PMYahoo Sports — Fantasy Football Defense Rankings Week 2: Eagles Lead, Seahawks and 49ers Draw Appealing Matchups
"Our Week 2 fantasy football defense rankings start with the Philadelphia Eagles at No. 1 for their road matchup with Tennessee.
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