Rams and Cardinals prepare for key Week 6 matchup at SoFi Stadium
Yahoo Sports • 1 min read • Latest: Oct 15, 2026, 8:18 PM
Last updated Oct 15, 2026
The Los Angeles Rams host the Arizona Cardinals on October 15 in a critical Week 6 matchup. The Rams enter the game as significant favorites and have historically performed well against the Cardinals. Key player matchups include DB Quentin Lake against TE Trey McBride and CB Jaylen Watson facing WR Michael Wilson. The Rams will rely on their defense to contain Arizona's offense, while the Cardinals look to exploit potential weaknesses in Los Angeles' lineup. Both teams are eager for a win as they aim to improve their standings in the division.
- •The Rams are favored by the largest margin all season entering this game.
- •Quentin Lake faces a critical matchup against tight end Trey McBride.
- •Jaylen Watson aims to limit the impact of WR Michael Wilson.
- •Alaric Jackson's suspension opens the door for David Quessenberry to start.
- •Byron Young looks to capitalize on Elijah Wilkinson's struggles on the offensive line.
- 8:18 PMYahoo Sports — 5 matchups that will decide Rams vs. Cardinals in Week 6
"The Rams have some major advantages over the Cardinals in Sunday's matchup at SoFi Stadium.
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