San Francisco 49ers and Los Angeles Rams meet Thursday in Australia

The San Francisco 49ers and Los Angeles Rams prepare to face off in Australia this Thursday night. The matchup serves as a high-profile regular season opener, following an offseason that saw the Rams add Myles Garrett and welcome back Aaron Donald, though Donald is inactive for this game. San Francisco looks to leverage a roster featuring Brock Purdy, Mike Evans, George Kittle, and Christian McCaffrey to challenge a Rams defense expected to adjust its personnel packages. The 49ers enter the contest with depth concerns on the defensive line following the loss of Alfred Collins, forcing a rotation of C.J. West, Kevin Givens, and James Thompson, Jr. to handle the Rams' rushing attack. Coaching strategies between Kyle Shanahan and Chris Shula will be central as both teams adapt to personnel shifts and the early-season pressure of an international primetime stage.

• 7:01 PMYahoo Sports — 3 things to watch for in 49ers-Rams: Get the ball out quickly, Brock Purdy