San Francisco 49ers enter season opener with multiple defensive line injuries
Yahoo Sports • 1 min read • Latest: Sep 4, 2026, 7:44 PM
Last updated Sep 4, 2026

The San Francisco 49ers head into their Thursday season opener against the Los Angeles Rams in Melbourne with significant concerns surrounding their defensive line. Sam Okuayinonu is ruled out for the matchup after sustaining a foot injury during the final practice. Mykel Williams remains on the physically unable to perform list and did not travel, while Romello Height continues to deal with an unspecified ankle injury. Star defensive end Nick Bosa traveled with the team but has not confirmed his availability following a recovery setback involving knee tendinitis. Keion White is the only defensive end on the roster without current injury concerns, though he continues to manage the aftereffects of an ankle injury sustained earlier this year. The team has not provided further updates on the personnel status as they prepare for the international game.
- •Sam Okuayinonu is ruled out for the game against the Los Angeles Rams.
- •Nick Bosa has not confirmed his status after suffering knee tendinitis.
- •Mykel Williams remains on the physically unable to perform list.
- •Keion White is the only healthy defensive end on the roster.
- •Romello Height is managing an unspecified ankle injury.
- 7:44 PMYahoo Sports — The 49ers defensive line is already hanging together by a thread
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