San Francisco 49ers prepare for season opener against Los Angeles Rams

Yahoo Sports1 min read • Latest: Sep 9, 2026, 8:39 PM

Last updated Sep 9, 2026

San Francisco 49ers prepare for season opener against Los Angeles Rams
Summary

The San Francisco 49ers head to Australia for a Week 1 game against the Los Angeles Rams. Heading into the matchup, the 49ers face several roster questions including significant depth issues on the defensive line following a season-ending injury to Alfred Collins. Additional injury concerns involve Sam Okuayinonu and Mykel Williams, forcing the team to evaluate its pass rush without several key players. On offense, the team must determine how to balance touches for Christian McCaffrey alongside reserves Kaelon Black and Jordan James., the coaching staff is expected to utilize a rotation at left guard to address a lack of depth at that position. Despite these personnel challenges, wide receiver Mike Evans is cleared to participate after an injury-plagued training camp.

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Status Watch
  • The 49ers are 2.5-point underdogs in the upcoming Week 1 game.
  • Alfred Collins is sidelined for the season with a torn patellar tendon.
  • The 49ers plan to rotate players at the left guard position.
  • Christian McCaffrey remains the primary focus of the offense despite workload management concerns.
  • Mike Evans is available for the season opener after recovering from a training camp injury.
Latest Updates
  • 8:39 PMYahoo Sports3 biggest questions for the 49ers in Week 1: Who will step up at DL?
What they're saying
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The Niners are heading into the season with a couple of key questions.

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