49ers defense strains as Bosa, West, and others face injuries
Yahoo Sports • 1 min read • Latest: Sep 25, 2026, 10:36 PM
Last updated Sep 25, 2026

The San Francisco 49ers are dealing with significant injuries on their defensive line, including Nick Bosa, who is expected to miss several weeks due to a calf injury. Bosa’s absence marks the sixth defensive lineman sidelined recently, alongside C.J. West and others. With the team's 2025 defensive line ranking last in sacks, rookie Gracen Halton is now expected to take on a larger role. Halton has played well in the first two weeks, with multiple pressures and an improving skill set recognized by the coaching staff. His performance will be crucial as the 49ers adjust their strategy moving forward.
- •Nick Bosa suffers a calf injury, expected to miss weeks.
- •Gracen Halton plays significant snaps due to injuries.
- •Halton recorded two pressures in Week 2 against the Dolphins.
- •Osa Odighizuwa leads the defensive line in pressures.
- •49ers aim to improve their defensive performance amid injuries.
- 10:36 PMYahoo Sports — One 49ers rookie will need to step up in big way after injuries
"The Niners are getting very shorthanded on the defensive line.
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