49ers edge Cardinals 36-30 amid injuries and offensive challenges

The San Francisco 49ers improved to 3-0 with a 36-30 victory against the Arizona Cardinals on September 27, 2026. Despite injuries to key players, including a weakened defensive line, the 49ers held off a late push from the Cardinals. Brock Purdy connected for four passing touchdowns, while Arizona's Jacoby Brissett responded with effective drives that kept the game competitive. The game featured a significant disparity in time of possession, with Arizona dominating at 38:44 compared to San Francisco's 21:16. The 49ers look to build on their success as they navigate their injury challenges in the coming weeks.

• 12:33 AMYahoo Sports — 49ers outscore Cardinals, overcome injuries, but can they sustain this kind of success?