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49ers face injury challenges ahead of Week 3 game against Cardinals

Yahoo Sports • 1 min read • Latest: Sep 27, 2026, 12:41 AM

Last updated Sep 27, 2026

49ers face injury challenges ahead of Week 3 game against Cardinals

Summary

The San Francisco 49ers prepare for their Week 3 matchup against the Arizona Cardinals while dealing with several player injuries. Key offensive players Christian McCaffrey and Trent Williams showed progress in practice and are expected to play. Conversely, defensive star Nick Bosa is officially out due to knee and calf injuries, joined by other defensive linemen with injuries. The status of receiver Mike Evans remains uncertain as he is questionable after limited practice leading into the game. These injuries could significantly affect both teams' dynamics on Sunday.

Source Links

Yahoo Sports

Status Watch

•McCaffrey and Williams participated fully in practice this week.
•Bosa will miss the game, impacting the 49ers' pass rush.
•Mike Evans is questionable, leaving his game status unclear.
•Demarcus Robinson is out due to an ankle injury, affecting the receiver rotation.
•Several defensive line injuries could benefit Arizona's offensive strategy.

Latest Updates

12:41 AMYahoo Sports — 49ers Week 3 injury report vs. Cardinals: What it means for fantasy football

What they're saying

"
The San Francisco 49ers head into their Week 3 matchup against the Arizona Cardinals dealing with a thin defensive line and a banged-up receiver room, though the offensive skill positions that matter most for fantasy managers appear to be trending in the right direction. Christian McCaffrey and Trent Williams both progressed from a Wednesday […] The post 49ers Week 3 injury report vs. Cardinals: What it means for fantasy football appeared first on ClutchPoints.
— Yahoo Sports

Related Teams & Leagues

Arizona Cardinals San Francisco 49ers NFL Football