49ers place Mykel Williams and Isaac Guerendo on injured reserve list

The San Francisco 49ers officially placed edge rusher Mykel Williams and running back Isaac Guerendo on the Reserve/Physically Unable to Perform list on Sunday. This move confirms that both players will miss at least the first four games of the 2026 season. Williams continues his recovery from a torn ACL sustained during Week 9 of his 2025 rookie season. Despite the team's ongoing concerns regarding his health, head coach Kyle Shanahan previously noted that Williams is progressing well. The designation forces both players to remain sidelined through the initial month of the schedule, though they may return to practice after the conclusion of Week 2. Williams enters the season with pressure to improve his pass-rush performance, as he struggled to establish consistency during his debut year before the knee injury occurred. The 49ers remain focused on his recovery as they prepare for the season opener against the Los Angeles Rams.

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