Analysts preview college football season opening games for LSU and Ole Miss

The 2026 college football season begins this weekend with marquee matchups featuring No. 11 LSU hosting Clemson and No. 9 Ole Miss playing Louisville. LSU enters the contest with high expectations following significant roster investments and the addition of Lane Kiffin. Analysts point to a talent disparity favoring the Tigers, though potential roster adjustments remain a factor for the early-season meeting. Meanwhile, No. 9 Ole Miss prepares for a Sunday clash against No. 24 Louisville. Historical data indicates that favorites in season-opening games between ranked opponents have struggled recently, with an 2-6 straight-up record over the last three years. These matchups serve as the initial test for programs navigating substantial personnel shifts and evolving rosters across the sport.

• 1:19 PMCBS Sports — The Six Pack: Picks for LSU vs. Clemson, Ole Miss vs. Louisville and Tom Fornelli's lock for Week 1