Arizona Cardinals face Los Angeles Chargers in week one season opener

The Arizona Cardinals open the 2026 NFL season on the road Sunday against the Los Angeles Chargers. Head coach Mike LaFleur enters his first season leading the Cardinals, who seek improvement after finishing the previous year ranked 31st in rushing. Arizona faces personnel challenges on the offensive line with Isaiah Adams ruled out and rookie Chase Bisontis on injured reserve. Running back Jeremiyah Love recently returned to practice in a limited capacity following a high ankle sprain, though Tyler Allgeier is expected to handle the bulk of carries. The Cardinals must contend with a Chargers pass rush featuring Khalil Mack and Tuli Tuipulotu, who combined for significant pressure and sack totals last season. The game marks a test for Arizona’s restructured offensive front against a Los Angeles team that secured a playoff berth a year ago under Jim Harbaugh.

• 12:00 PMYahoo Sports — Here are 3 keys for the Cardinals to defeat the Chargers