Arizona Cardinals prepare for 2026 season against San Francisco 49ers
Yahoo Sports • 1 min read • Latest: Aug 2, 2026, 5:26 AM
Last updated Aug 2, 2026
The Arizona Cardinals will face the San Francisco 49ers twice in the upcoming 2026 NFL season, with the first meeting in Week 3 on the road and the second in Week 18 at home. Discussions among analysts focus on the 49ers' challenging 2025 season, where they made the playoffs despite numerous injuries. Changes in the coaching staff, including the departure of Robert Saleh and the appointment of Raheem Morris as defensive coordinator, have prompted conversations about the team's future. Analysts also explore expectations for the 49ers as they head into 2026.
- •Cardinals and 49ers will meet twice in the regular season.
- •First game is scheduled for Week 3 on the road.
- •Second game at home is set for Week 18.
- •49ers made playoffs in 2025, overcoming significant injuries.
- •Raheem Morris replaces Robert Saleh as defensive coordinator.
- 5:26 AMYahoo Sports — Arizona Cardinals 2026 opponent preview: San Francisco 49ers offseason
"Niners Wire lead writer Kyle Madson joins Jess Root on the podcast to preview the San Francisco 49ers.
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