Brock Purdy leads 49ers offense in close matchup against Cardinals
Yahoo Sports • 1 min read • Latest: Sep 27, 2026, 11:17 PM
Last updated Sep 27, 2026

The San Francisco 49ers hosted the Arizona Cardinals on September 27, 2026, in a competitive matchup highlighted by Brock Purdy's performance. Early in the game, Deebo Samuel scored a touchdown, but the 49ers' defense struggled with injuries. The 49ers maintained a narrow lead at halftime, ending the period at 17-6. Purdy orchestrated quick scoring drives, while the Cardinals responded effectively, making it a close game. Multiple key players were sidelined due to injuries, including Mike Evans and Trent Williams, adding pressure to the 49ers' depth.
- •49ers lead 17-6 at halftime against the Cardinals.
- •Brock Purdy's quick scoring drives highlight the second half.
- •Mike Evans ruled out due to a rib injury.
- •Trent Williams leaves with a stinger during a touchdown play.
- •Injuries impact both teams' defensive performance.
- 11:25 PMYahoo Sports — Purdy throws 4 TD passes to lead the injury-depleted 49ers to a 36-30 win vs. the Cardinals
- 11:17 PMYahoo Sports — Brock Purdy bails out the 49ers’ defense in a shootout win over the Cardinals
"Brock Purdy threw four touchdown passes, with the first coming on a trick play, and the injury-depleted San Francisco 49ers held on for a 36-30 victory over the Arizona Cardinals on Sunday. San Francisco lost wide receiver Mike Evans to a rib injury in the first half and left tackle Trent Williams to a stinger in the second half, but still managed to hold on to start 3-0 for the third time in the last four seasons. The game began well for the Niners before the injuries started mounting and they found themselves in a tight game against the Cardinals (1-2), who have lost 22 of their last 26 games in the division.
"The 49ers were decimated by injuries, but held on with a home win.
Sources
External links- Yahoo SportsSep 27, 2026, 11:25 PMPurdy throws 4 TD passes to lead the injury-depleted 49ers to a 36-30 win vs. the Cardinals
Brock Purdy threw four touchdown passes, with the first coming on a trick play, and the injury-depleted San Francisco 49ers held on for a 36-30 victory over the Arizona Cardinals on Sunday. San Francisco lost wide receiver Mike Evans to a rib injury in the first half and left tackle Trent Williams to a stinger in the second half, but still managed to hold on to start 3-0 for the third time in the last four seasons. The game began well for the Niners before the injuries started mounting and they found themselves in a tight game against the Cardinals (1-2), who have lost 22 of their last 26 games in the division.
- Yahoo SportsSep 27, 2026, 11:17 PMBrock Purdy bails out the 49ers’ defense in a shootout win over the Cardinals
The 49ers were decimated by injuries, but held on with a home win.
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