League: NFL Sport: Football Country: United States Category: Scores & Results

Cardinals fall to 49ers 36-30 amid defensive struggles

Yahoo Sports • 1 min read • Latest: Sep 28, 2026, 10:46 PM

Last updated Sep 28, 2026

Cardinals fall to 49ers 36-30 amid defensive struggles

Summary

The Arizona Cardinals lost to the San Francisco 49ers 36-30 on September 28, 2026, marking their eighth consecutive defeat against NFC West opponents. The Cardinals' offense performed well, with quarterback Jacoby Brissett completing 38 of 52 passes for 280 yards and two touchdowns. However, the defense struggled significantly, allowing San Francisco to score at least 30 points for the sixth straight game. Arizona’s head coach Mike LaFleur highlighted the need for improvement in coaching and execution across all phases. The Cardinals will next face the New York Giants on October 5.

Source Links

Yahoo Sports

By the Numbers

•Cardinals drop to 1-2 after loss to 49ers.
•Defense allowed 30+ points for sixth straight NFC West game.
•Brissett completed 38 passes for 280 yards and 2 touchdowns.
•Next game is against the New York Giants on October 5.

Latest Updates

10:46 PMYahoo Sports — The Arizona Cardinals of 2026 looked a little like the 2025 version on Sunday. That's not good

What they're saying

"
The Arizona Cardinals of 2026 looked a lot like the 2025 version against the San Francisco 49ers on Sunday. The Cardinals (1-2) lost their second game in a row on Sunday, falling to the 49ers 36-30 for their eighth straight defeat against an NFC West opponent. The game had a familiar theme that harkened back to last year's 3-14 season — the offense was pretty good, the defense was pretty bad and penalties were a problem, particularly in the first half.
— Yahoo Sportsby DAVID BRANDT

Related Teams & Leagues

Arizona Cardinals San Francisco 49ers NFL Football