Deebo Samuel out with hamstring injury, Nick Bosa nearing return for 49ers

Deebo Samuel will be sidelined indefinitely after injuring his hamstring during the 49ers' 32-29 victory against the Seahawks on October 8. Head coach Kyle Shanahan confirmed Samuel's absence, noting he had two catches for 21 yards in that game. With Samuel out, the 49ers will rely on Brandin Cooks, Jacob Cowing, and Jordan Watkins alongside Mike Evans. In a more positive update, Shanahan indicated that defensive end Nick Bosa could return in Week 6 after missing three games due to a calf injury. The 49ers are set to face the Commanders next Monday night.

• 10:14 PMYahoo Sports — Deebo Samuel to miss time with hamstring injury, Nick Bosa could return this week