Kevin Harlan and Trent Green call Chargers opener against Cardinals

The Los Angeles Chargers host the Arizona Cardinals in a regular season opening game on Sunday, September 13. Kickoff is scheduled for 1:25 pm PT with CBS providing live television coverage. Kevin Harlan will handle play-by-play duties alongside analyst Trent Green. The Chargers enter the season as 9.5-point favorites in the third year under head coach Jim Harbaugh, marking the debut of offensive coordinator Mike McDaniel. Arizona begins a transition period under head coach Mike LaFleur with a reconstructed offensive line protecting quarterback Jacoby Brissett. The Cardinals won the most recent meeting between the two teams in 2024 by a score of 17-15, though the Chargers hold an 11-5 advantage in the overall series.

• 8:36 PMYahoo Sports — Announcers set for Chargers vs. Cardinals Week 1 opener