Lions secure 45-21 victory over Cardinals in Week 5 matchup

The Detroit Lions defeated the Arizona Cardinals 45-21 on October 11, 2026, at State Farm Stadium. After a sluggish start, the Lions turned around their performance in the second quarter, with offensive play and a strong defensive effort contributing to the win. Detroit's offensive line struggled early, allowing three sacks in the first quarter, but improved significantly as the game progressed. Defensive end DJ Wonnum shone with two sacks, bolstering the pass rush. With a bye week ahead, the Lions aim to address slow starts before their next game against the Packers.

• 12:10 AMYahoo Sports — 6 takeaways from Lions’ strong win against Cardinals