Trey Mancini retires from MLB after colon cancer recovery
5 sources • 1 min read • Latest: Aug 18, 2026, 7:56 PM
Last updated Aug 18, 2026
Trey Mancini announced his retirement from Major League Baseball on August 18, 2026, after a career that included a battle with colon cancer. After missing the entire 2020 season for treatment, Mancini returned to play four more seasons, including winning a World Series with the Houston Astros in 2022. He expressed deep gratitude to fans, teammates, and medical staff in his announcement on Instagram. Mancini also played briefly for the Los Angeles Angels earlier this season before deciding to retire.
- •Mancini returned to MLB in 2021 after battling colon cancer.
- •He won the AL Comeback Player of the Year award in 2021.
- •Mancini was part of the 2022 World Series-winning Astros.
- •He played with the Angels this season before retiring.
- •Mancini thanked fans and medical staff in his retirement announcement.
- 7:56 PMYahoo Sports — Trey Mancini retires after a 5-game Angels comeback, ending a cancer survivor’s MLB run
- 7:42 PMESPN MLB — Cancer survivor, 1B Mancini says he's retiring
- 6:01 PMYahoo Sports — Orioles' medical hero Trey Mancini announces retirement
- 2:59 PMYahoo Sports — Trey Mancini, Orioles standout who returned after colon cancer, retires from MLB: 'I have immense gratitude'
"Trey Mancini, the AL Comeback Player of the Year in 2021 for his return from colon cancer who then helped Houston win the 2022 World Series, announced his retirement.
"Trey Mancini, who came back from colon cancer and most recent was playing with the Angels, announce his retirement on Tuesday.
"The 34-year-old cancer survivor and 2021 AL Comeback Player of the Year decided to leave the game on his own terms.
Sources
External links- Yahoo SportsAug 18, 2026, 7:56 PMTrey Mancini retires after a 5-game Angels comeback, ending a cancer survivor’s MLB run
Trey Mancini, the AL Comeback Player of the Year in 2021 for his return from colon cancer who then helped Houston win the 2022 World Series, announced his retirement.
- ESPN MLBAug 18, 2026, 7:42 PMCancer survivor, 1B Mancini says he's retiring
Trey Mancini, who came back from colon cancer and most recent was playing with the Angels, announce his retirement on Tuesday.
- Yahoo SportsAug 18, 2026, 6:01 PMOrioles' medical hero Trey Mancini announces retirement
The 34-year-old cancer survivor and 2021 AL Comeback Player of the Year decided to leave the game on his own terms.
- Yahoo SportsAug 18, 2026, 2:59 PMTrey Mancini, Orioles standout who returned after colon cancer, retires from MLB: 'I have immense gratitude'
Trey Mancini returned to the majors after missing the 2020 MLB season due to colon cancer.
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