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Penn State opens as 39.5-point favorite against Buffalo this Saturday

Yahoo Sports • 1 min read • Latest: Sep 13, 2026, 4:48 PM

Last updated Sep 13, 2026

Penn State opens as 39.5-point favorite against Buffalo this Saturday

Summary

Penn State enters its final non-conference matchup of the regular season as a heavy favorite against Buffalo. Oddsmakers have set the Nittany Lions as 39.5-point favorites for the game at home this Saturday. Buffalo arrives at the contest with a 1-1 record following a 21-17 victory over Albany and a 33-20 loss to Florida International. Penn State previously defeated Marshall 45-0 and Temple 27-9 to begin its campaign. The two programs have met twice before, with the Nittany Lions securing victories in both 2015 and 2019. Kickoff for the game is scheduled for noon on the Big Ten Network.

Source Links

Yahoo Sports

By the Numbers

•Penn State hosts Buffalo on Saturday at noon on the Big Ten Network.
•The Nittany Lions open the matchup as 39.5-point favorites.
•Buffalo holds a 1-1 record entering the game.
•Penn State leads the all-time series 2-0 against the Bulls.

Latest Updates

4:48 PMYahoo Sports — Penn State Opens as Heavy Favorite Over Buffalo

What they're saying

"
Penn State is a heavy favorite to make it out of non-conference play unscathed. The Nittany Lions opened as a 39.5-point favorite over Buffalo, its final non-conference opponent of the regular season. Buffalo is off to a 1-1 start after sneaking past FCS Albany in week one, 21-17, before falling to Florida International, 33-20, on […]
— Yahoo Sports

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